![]() The concentrations of the chemical in air that kills 50% of the test animals during the observation period is the LC 50 value. ![]() The animals are clinically observed for up to 14 days. LC values usually refer to the concentration of a chemical in air but in environmental studies it can also mean the concentration of a chemical in water.Īccording to the (Organisation for Economic Cooperation and Development) (OECD) Guidelines for the Testing of Chemicals, a traditional experiment involves groups of animals exposed to a concentration (or series of concentrations) for a set period of time (usually 4 hours). The LD 50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common. ![]() It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (for smaller animals) or per kilogram (for bigger test subjects) of the body weight of the test animal. Toxicologists can use many kinds of animals but most often testing is done with rats and mice. The LD 50 is one way to measure the short-term poisoning potential (acute toxicity) of a material. LD 50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals.
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